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Neutrophil Diapedesis: Paracellular or Transcellular?

Peter R. Kvietys and Martin Sandig

P. R. Kvietys is in the Vascular Biology Program at the Lawson Health Research Institute, N6A 4G5; and M. Sandig is in the Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.
To reach an inflammatory site in the interstitium, circulating neutrophils (PMN) must first traverse the endothelial barrier. Whether PMN emigrate between endothelial cells (paracellular pathway) or through the endothelial cells proper (transcellular pathway) is controversial. Herein, we present anatomic, functional, and teleological arguments that support both points of view. An attempt is also made to reconcile this apparent controversy.

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