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News Physiol Sci 16: 23-28, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 1, 23-28, February 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Gastroduodenal Mucosal Alkaline Secretion and Mucosal Protection

Gunnar Flemström and Jon I. Isenberg

G. Flemström is in the Department of Physiology at Uppsala University, SE-751 23 Uppsala, Sweden, and J. I. Isenberg is in the Department of Medicine, University of California at San Diego, San Diego, CA 92103-8413.
The gastroduodenal mucosa is a dynamic barrier restricting entry of gastric acid and other potentially hostile luminal contents. Mucosal HCO3– is a key element in preventing epithelial damage, and knowledge about HCO3– transport processes, including the role of the cystic fibrosis transmembrane conductance regulator channel, and their neurohumoral control are in rapid progress.




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