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News Physiol Sci 16: 33-37, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 1, 33-37, February 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Neurogenic Inflammation in Human and Rodent Skin

M. Schmelz and L. J. Petersen

M. Schmelz is in the Department of Physiology, University of Erlangen, 91054 Erlangen, Germany, and L. J. Petersen is in the Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, DK-2400 Copenhagen, Denmark.
The combination of vasodilation and protein extravasation following activation of nociceptors has been termed "neurogenic inflammation." In contrast to rodents, no neurogenic protein extravasation can be elicited in healthy human skin. Dermal microdialysis has considerably increased our knowledge about neurogenic inflammation in human skin, including the involvement of mast cells.




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