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News Physiol Sci 16: 38-41, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 1, 38-41, February 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Physiological Properties of Blood Substitutes

Donat R. Spahn and Thomas Pasch

D. R. Spahn is Professor of Anesthesiology and T. Pasch is Professor and Chairman at the Institut für Anästhesiologie, UniversitätsSpital, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Blood substitutes (modified hemoglobin solutions, perfluorocarbon emulsions) serve as artificial oxygen carriers and are alternatives to blood transfusions. Hemoglobin solutions mimic the sigmoidal oxygen dissociation curve of natural blood. Perflurocarbon emulsions exhibit a linear relation between PO2 and dissolved oxygen. The most advanced substances may enter medicine in few years.




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