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News Physiol Sci 16: 49-55, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 2, 49-55, April 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Skeletal and Cardiac Muscle Contractile Activation: Tropomyosin "Rocks and Rolls"

A. M. Gordon, M. Regnier and E. Homsher

A. M. Gordon is in the Department of Physiology and Biophysics and M. Regnier is in the Department of Bioengineering, University of Washington, Seattle, WA. E. Homsher is in the Department of Physiology, University of California at Los Angeles, Los Angeles, CA.
Changes in thin filament structure induced by Ca2+ binding to troponin and subsequent strong cross-bridge binding regulate additional strong cross-bridge attachment, force development, and dependence of force on sarcomere length in skeletal and cardiac muscle. Variations in activation properties account for functional differences between these muscle types.




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