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M. J. Tuvim, R. Adachi, S. Hoffenberg, and B. F. Dickey are at Baylor College of Medicine and Houston VA Medical Center, Departments of Medicine and of Molecular Physiology and Biophysics, 2002 Holcombe Blvd., Houston TX 77030.
Membrane proteins, membrane lipids, and luminal contents are exchanged among the intracellular compartments of eukaryotic cells by vesicular transport. This process must be highly ordered to maintain cellular architecture in the face of rapid membrane turnover. The Ras-related Rab GTPases play multiple roles in regulating this traffic.
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