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News Physiol Sci 16: 61-65, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 2, 61-65, April 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Smooth Muscle Excitation-Contraction Coupling: a Role for Caveolae and Caveolins?

Michael J. Taggart

M. J. Taggart is in the Department of Medicine and Maternal and Fetal Health Research Centre, University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, England.
Agonist stimulation of smooth muscle contractility involves integration of many signal-transducing events from the plasma membrane to myofilaments in the cytoplasm. Recent evidence suggests an important role for membranous invaginations termed caveolae, and their integral protein components caveolins, in the coordination of extracellular contractile stimuli and intracellular effectors in smooth muscle.




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