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Brain Glucose Transporters: Relationship to Local Energy Demand

Roman Duelli and Wolfgang Kuschinsky

R. Duelli and W. Kuschinsky are in the Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany.
Glucose, the major fuel in the brain, is transported across the cell membranes by facilitated diffusion mediated by glucose transporter proteins. Essentially two types of glucose transporters are localized in the membranes of brain endothelial cells, astrocytes, and neurons. Their densities are well adjusted to changes in local energy demand.

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