HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (37) Citing Articles via Google Scholar Google Scholar Articles by Kubes, P. Articles by Kerfoot, S. M. Search for Related Content PubMed PubMed Citation Articles by Kubes, P. Articles by Kerfoot, S. M.

Leukocyte Recruitment in the Microcirculation: the Rolling Paradigm Revisited

Paul Kubes and Steven M. Kerfoot

P. Kubes and S. M. Kerfoot are in the Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1.
Intravital microscopy has done much to elucidate the cascade of events involved in the recruitment of leukocytes to sites of inflammation. Here we review the physiological relevance of leukocyte rolling and some of the important subtleties of this process, highlighting limitations in our knowledge and directions for future investigation.

This article has been cited by other articles:

				B. Vollmar and M. D. Menger The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair Physiol Rev, October 1, 2009; 89(4): 1269 - 1339. [Abstract] [Full Text] [PDF]

				L. Liu, K. D. Puri, J. M. Penninger, and P. Kubes Leukocyte PI3K{gamma} and PI3K{delta} have temporally distinct roles for leukocyte recruitment in vivo Blood, August 15, 2007; 110(4): 1191 - 1198. [Abstract] [Full Text] [PDF]

				E. M. Wagner and J. Jenkins Effects of airway distension on leukocyte recruitment in the mouse tracheal microvasculature J Appl Physiol, April 1, 2007; 102(4): 1528 - 1534. [Abstract] [Full Text] [PDF]

				X. Zhang, E. P. Wojcikiewicz, and V. T. Moy Dynamic Adhesion of T Lymphocytes to Endothelial Cells Revealed by Atomic Force Microscopy Experimental Biology and Medicine, September 1, 2006; 231(8): 1306 - 1312. [Abstract] [Full Text] [PDF]

				S. M. Kerfoot, M. U. Norman, B. M. Lapointe, C. S. Bonder, L. Zbytnuik, and P. Kubes Reevaluation of P-Selectin and {alpha}4 Integrin as Targets for the Treatment of Experimental Autoimmune Encephalomyelitis J. Immunol., May 15, 2006; 176(10): 6225 - 6234. [Abstract] [Full Text] [PDF]

				S. C. Schafer, D. N. Sehrt, M. Kamler, H. Jakob, and H.-A. Lehr Paradoxical attenuation of leukocyte rolling in response to ischemia- reperfusion and extracorporeal blood circulation in inflamed tissue Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H330 - H335. [Abstract] [Full Text] [PDF]

				J. M. Hwang, J. Yamanouchi, P. Santamaria, and P. Kubes A Critical Temporal Window for Selectin-dependent CD4+ Lymphocyte Homing and Initiation of Late-Phase Inflammation in Contact Sensitivity J. Exp. Med., May 3, 2004; 199(9): 1223 - 1234. [Abstract] [Full Text] [PDF]

				P. Kubes, B. Heit, G. van Marle, J. B. Johnston, D. Knight, A. Khan, and C. Power In Vivo Impairment of Neutrophil Recruitment during Lentivirus Infection J. Immunol., November 1, 2003; 171(9): 4801 - 4808. [Abstract] [Full Text] [PDF]

				S. Mortier, A. S. de Vriese, R. M. McLoughlin, N. Topley, T. P. Schaub, J. Passlick-Deetjen, and N. H. Lameire Effects of Conventional and New Peritoneal Dialysis Fluids on Leukocyte Recruitment in the Rat Peritoneal Membrane J. Am. Soc. Nephrol., May 1, 2003; 14(5): 1296 - 1306. [Abstract] [Full Text] [PDF]