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Leukocyte Recruitment in the Microcirculation: the Rolling Paradigm Revisited

Paul Kubes and Steven M. Kerfoot

P. Kubes and S. M. Kerfoot are in the Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1.
Intravital microscopy has done much to elucidate the cascade of events involved in the recruitment of leukocytes to sites of inflammation. Here we review the physiological relevance of leukocyte rolling and some of the important subtleties of this process, highlighting limitations in our knowledge and directions for future investigation.

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