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Physiological Insights from Genetic Manipulation of the Renin-Angiotensin System

David E. Stec and Curt D. Sigmund

D. E. Stec and C. D. Sigmund are in the Departments of Internal Medicine and Physiology and Biophysics, The University of Iowa College of Medicine, Iowa City, Iowa 52242.
The renin-angiotensin system is one of the most widely studied endocrine systems. It has an important role in the regulation of normal homeostasis, and disturbances in this system may be important in numerous pathological states. This review will focus on the major insights and important questions raised from gene targeting of this system.

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