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News Physiol Sci 16: 84-88, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 2, 84-88, April 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Vascular Endothelium: Checkpoint for Inflammation and Immunity

Barbara C. Biedermann

B. C. Biedermann is in the Department of Internal Medicine, University Hospital, Kantonsspital Bruderholz, CH-4101 Bruderholz, Switzerland.
Vascular endothelial cells play a threefold role in the interaction with leukocytes. First, they are gatekeepers in leukocyte recruitment to inflammatory foci and lymphocyte homing to secondary lymphoid organs. Second, they modulate leukocyte activation. Finally, they are targets of leukocyte-derived molecules, resulting either in endothelial cell activation or death.




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