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News Physiol Sci 16: 88-91, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 2, 88-91, April 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

An Autocrine/Paracrine Mechanism Triggered by Myocardial Stretch Induces Changes in Contractility

Horacio E. Cingolani, Néstor G. Pérez and María C. Camilión de Hurtado

H. E. Cingolani, N. G. Pérez, and M. C. Camilión de Hurtado are at the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina.
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.




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