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News Physiol Sci 16: 101-106, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 3, 101-106, June 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Intracellular Ca2+ Release Sparks Atrial Pacemaker Activity

Stephen L. Lipsius, Jörg Hüser and Lothar A. Blatter

S. L. Lipsius and L. A. Blatter are in the Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153. J. Hüser is at Bayer AG, 42096 Wuppertal, Germany.
Electrical excitation of the mammalian heart originates from specialized pacemaker cells in the right atrium. Pacemaker activity depends on multiple ion channels and transport mechanisms that reside primarily within the plasma membrane. However, recent evidence indicates that intracellular Ca2+ release from the sarcoplasmic reticulum also contributes importantly to atrial pacemaker function.




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