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News Physiol Sci 16: 106-109, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 3, 106-109, June 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Polyamines: New Cues in Cellular Signal Transduction

Uriel Bachrach, Yong-Chun Wang and Amalia Tabib

U. Bachrach, Y.-C. Wang, and A. Tabib are in the Department of Molecular Biology, Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as {alpha}-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).




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