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News Physiol Sci 16: 110-113, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 3, 110-113, June 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Pleiotropic Functions and Tissue-Specific Expression of Erythropoietin

Ryuzo Sasaki, Seiji Masuda and Masaya Nagao

R. Sasaki, S. Masuda, and M. Nagao are in the Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Erythropoietin (EPO) is produced in the brain, uterus, and oviduct. Brain EPO plays a neuroprotective role, and uterine EPO is likely involved in estrogen-dependent angiogenesis. Hypoxic induction of brain EPO markedly differs from that in the kidney. EPO in the uterus and oviduct is estrogen inducible.




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