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News Physiol Sci 16: 114-118, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 3, 114-118, June 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Molecular Physiology of Renal p-Aminohippurate Secretion

Gerhard Burckhardt, Andrew Bahn and Natascha A. Wolff

G. Burckhardt, A. Bahn, and N. A. Wolff are at the Zentrum Physiologie und Pathophysiologie, Georg-August-Universität, 37073 Göttingen, Germany.
Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs by exchange with intracellular {alpha}-ketoglutarate and is mediated by the organic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.




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