| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
S. Schuldiner, D. Granot, S. Steiner Mordoch, S. Ninio, D. Rotem, M. Soskin, and H. Yerushalmi are at the Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel. C. G. Tate is at the MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
EmrE is a multidrug transporter from Escherichia coli that functions as a homooligomer and is unique in its small size. In each monomer there are four tightly packed transmembrane segments and one membrane-embedded charged residue. This residue provides the basis for the coupling mechanism as part of a binding site "time shared" by substrates and protons.
This article has been cited by other articles:
|
|
 |
|
  Y. Elbaz, T. Salomon, and S. Schuldiner Identification of a Glycine Motif Required for Packing in EmrE, a Multidrug Transporter from Escherichia coli J. Biol. Chem., May 2, 2008; 283(18): 12276 - 12283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lehner, D. Basting, B. Meyer, W. Haase, T. Manolikas, C. Kaiser, M. Karas, and C. Glaubitz The Key Residue for Substrate Transport (Glu14) in the EmrE Dimer Is Asymmetric J. Biol. Chem., February 8, 2008; 283(6): 3281 - 3288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Chen, O. Pornillos, S. Lieu, C. Ma, A. P. Chen, and G. Chang X-ray structure of EmrE supports dual topology model PNAS, November 27, 2007; 104(48): 18999 - 19004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Adam, N. Tayer, D. Rotem, G. Schreiber, and S. Schuldiner The fast release of sticky protons: Kinetics of substrate binding and proton release in a multidrug transporter PNAS, November 13, 2007; 104(46): 17989 - 17994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nara, T. Kouyama, Y. Kurata, T. Kikukawa, S. Miyauchi, and N. Kamo Anti-parallel Membrane Topology of a Homo-dimeric Multidrug Transporter, EmrE J. Biochem., November 1, 2007; 142(5): 621 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ganas, M. Mihasan, G. L. Igloi, and R. Brandsch A two-component small multidrug resistance pump functions as a metabolic valve during nicotine catabolism by Arthrobacter nicotinovorans Microbiology, May 1, 2007; 153(5): 1546 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rotem, S. Steiner-Mordoch, and S. Schuldiner Identification of Tyrosine Residues Critical for the Function of an Ion-coupled Multidrug Transporter J. Biol. Chem., July 7, 2006; 281(27): 18715 - 18722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Pornillos, Y.-J. Chen, A. P. Chen, and G. Chang X-ray Structure of the EmrE Multidrug Transporter in Complex with a Substrate Science, December 23, 2005; 310(5756): 1950 - 1953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sharoni, S. Steiner-Mordoch, and S. Schuldiner Exploring the Binding Domain of EmrE, the Smallest Multidrug Transporter J. Biol. Chem., September 23, 2005; 280(38): 32849 - 32855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Lomovskaya and M. Totrov Vacuuming the Periplasm J. Bacteriol., March 15, 2005; 187(6): 1879 - 1883. [Full Text] [PDF]
|
|
|
|
|
|
A. B. Weinglass, M. Soskine, J.-L. Vazquez-Ibar, J. P. Whitelegge, K. F. Faull, H. R. Kaback, and S. Schuldiner Exploring the Role of a Unique Carboxyl Residue in EmrE by Mass Spectrometry J. Biol. Chem., March 4, 2005; 280(9): 7487 - 7492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rotem and S. Schuldiner EmrE, a Multidrug Transporter from Escherichia coli, Transports Monovalent and Divalent Substrates with the Same Stoichiometry J. Biol. Chem., November 19, 2004; 279(47): 48787 - 48793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-E. Gottschalk, M. Soskine, S. Schuldiner, and H. Kessler A Structural Model of EmrE, a Multi-Drug Transporter from Escherichia coli Biophys. J., June 1, 2004; 86(6): 3335 - 3348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Soskine, Y. Adam, and S. Schuldiner Direct Evidence for Substrate-induced Proton Release in Detergent-solubilized EmrE, a Multidrug Transporter J. Biol. Chem., March 12, 2004; 279(11): 9951 - 9955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ma and G. Chang Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli PNAS, March 2, 2004; 101(9): 2852 - 2857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Elbaz, S. Steiner-Mordoch, T. Danieli, and S. Schuldiner In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state PNAS, February 10, 2004; 101(6): 1519 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gutman, S. Steiner-Mordoch, and S. Schuldiner An Amino Acid Cluster around the Essential Glu-14 Is Part of the Substrate- and Proton-binding Domain of EmrE, a Multidrug Transporter from Escherichia coli J. Biol. Chem., April 25, 2003; 278(18): 16082 - 16087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ninio and S. Schuldiner Characterization of an Archaeal Multidrug Transporter with a Unique Amino Acid Composition J. Biol. Chem., March 28, 2003; 278(14): 12000 - 12005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Soskine, S. Steiner-Mordoch, and S. Schuldiner Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer PNAS, September 17, 2002; 99(19): 12043 - 12048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rotem, N. Sal-man, and S. Schuldiner In Vitro Monomer Swapping in EmrE, a Multidrug Transporter from Escherichia coli, Reveals That the Oligomer Is the Functional Unit J. Biol. Chem., December 14, 2001; 276(51): 48243 - 48249. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
