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News Physiol Sci 16: 145-151, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 4, 145-151, August 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Energizing Epithelial Transport with the Vacuolar H+-ATPase

Klaus W. Beyenbach

Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853
The Ussing model has long provided the conceptual foundation for understanding epithelial transport mechanisms energized by the Na+-K+-ATPase. Plasma membranes may also use the vacuolar (V-type) H+-ATPase as the primary energy source of membrane and epithelial transport. A pure electrogenic pump, the V-type H+-ATPase energizes not only membranes it inhabits but also other transport pathways via electrical coupling.




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