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News Physiol Sci 16: 152-156, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 4, 152-156, August 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Intrarenal Endothelin System and Hypertension

Zaid A. Abassi1, Samer Ellahham2,3, Joseph Winaver1 and Aaron Hoffman4

1 Department of Physiology and Biophysics, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology and
4 Department of Vascular Surgery and Transplantation, Rambam Medical Center, 31096 Haifa, Israel; and
2 Exercise and Pharmacological Stress Imaging Laboratory and
3 Vascular Biology Laboratory, Division of Cardiology, Washington Hospital Center, Washington, DC 20010
The kidney is both a source of endothelin (ET) generation and an important target organ of this peptide. The highest concentrations of ET-1 in the body exist in the renal medulla, where it mediates natriuretic and diuretic effects through the ETB receptor subtype. It is proposed that aberrations in the renal ET system may lead to sodium and water retention and subsequently to the development of hypertension.




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