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ClC Chloride Channels in Epithelia: Recent Progress and Remaining Puzzles

N. K. Wills¹ and P. Fong²

¹ Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77551; and
² Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
ClC chloride channels are widely expressed in epithelia. Recent insights into the roles of specific ClC channels have emerged from molecular and immunolocalization studies, mouse knockout models, and the linkage of mutations of these channels to the human hereditary diseases Bartter's syndrome and Dent's disease.

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