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News Physiol Sci 16: 171-173, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 4, 171-173, August 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Molecular Recognition by Induced Fit: How Fit is the Concept?

Hans Rudolf Bosshard

Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland
Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.




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