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News Physiol Sci 16: 185-190, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 4, 185-190, August 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Reactive Species in Viral Pneumonitis: Lessons From Animal Models

Ian Davis1 and Sadis Matalon2

1 Departments of Comparative Medicine and
2 Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35233-6810
Recent evidence suggests that pneumonitis induced by many important human viral pathogens may result from exuberant generation of reactive species by inflammatory cells in response to infection. This review summarizes current evidence from animal model studies regarding the beneficial (antiviral) and harmful (tissue-damaging) effects of reactive species for the host.




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