Physiology Journal of Applied Physiology
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News Physiol Sci 16: 197-200, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 5, 197-200, October 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Stimulus-Secretion Coupling and Mitochondrial Metabolism in Steroid-Secreting Cells

András Spät1, János G. Pitter1, Tibor Rohács2 and György Szabadkai1

1 Department of Physiology, Faculty of Medicine, Semmelweis University, H-1444 Budapest, Hungary; and
2 Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029

Ca2+ signal in high-Ca2+ perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca2+-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca2+ signals may also augment mitochondrial Ca2+ concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.




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