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News Physiol Sci 16: 201-207, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 5, 201-207, October 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Unlocking Mysteries of Gut Sensory Transmission: Is Adenosine the Key?

Fievos L. Christofi

Department of Anesthesiology, Physiology, and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210
Endogenous adenosine acts at pre- or postsynaptic A1, A2, or A3 receptors to inhibit synaptic transmission in intrinsic primary afferent/AH neurons, S neurons, and mucosal and motility reflexes. Adenosine provides dual modulation of adenylyl cyclases. Its modulation of sensory transmission may be of therapeutic potential in gut inflammation, ischemia, and constipation.




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