|
|
||||||||
MRC Anatomical Neuropharmacology Unit, University of Oxford, OX1 3TH Oxford, UK
ATP-sensitive potassium (KATP) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of KATP channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential KATP channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.
This article has been cited by other articles:
![]() |
L. Huang, B. Li, W. Li, H. Guo, and F. Zou ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity Carcinogenesis, May 1, 2009; 30(5): 737 - 744. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Buttner, A. Bitto, J. Ring, M. Augsten, P. Zabrocki, T. Eisenberg, H. Jungwirth, S. Hutter, D. Carmona-Gutierrez, G. Kroemer, et al. Functional Mitochondria Are Required for {alpha}-Synuclein Toxicity in Aging Yeast J. Biol. Chem., March 21, 2008; 283(12): 7554 - 7560. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Gautier, J. Auger, C. Legros, and B. Lapied Calcium-Activated Potassium Channels in Insect Pacemaker Neurons as Unexpected Target Site for the Novel Fumigant Dimethyl Disulfide J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 149 - 159. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Wu, J. Hu, Y.-P. Chen, T. Takeo, S. Suga, J. DeChon, Q. Liu, K.-C. Yang, P. A. St. John, G. Hu, et al. Iptakalim Modulates ATP-Sensitive K+ Channels in Dopamine Neurons from Rat Substantia Nigra Pars Compacta J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 155 - 164. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. V. Avshalumov and M. E. Rice Activation of ATP-sensitive K+ (KATP) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release PNAS, September 30, 2003; 100(20): 11729 - 11734. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Dugravot, F. Grolleau, D. Macherel, A. Rochetaing, B. Hue, M. Stankiewicz, J. Huignard, and B. Lapied Dimethyl Disulfide Exerts Insecticidal Neurotoxicity Through Mitochondrial Dysfunction and Activation of Insect KATP Channels J Neurophysiol, July 1, 2003; 90(1): 259 - 270. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |