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News Physiol Sci 16: 214-217, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 5, 214-217, October 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

ATP-Sensitive Potassium Channels in Dopaminergic Neurons: Transducers of Mitochondrial Dysfunction

Birgit Liss and Jochen Roeper

MRC Anatomical Neuropharmacology Unit, University of Oxford, OX1 3TH Oxford, UK
ATP-sensitive potassium (KATP) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of KATP channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential KATP channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.




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