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News Physiol Sci 16: 239-243, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 5, 239-243, October 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Mechanisms of Surfactant Exocytosis in Alveolar Type II Cells In Vitro and In Vivo

Paul Dietl, Thomas Haller, Norbert Mair and Manfred Frick

Department of Physiology, University of Innsbruck, A-6020 Innsbruck, Austria
Surfactant secretion must be regulated to maintain a low surface tension in the lung during various conditions such as exercise. In vitro studies reveal a slow, unique exocytotic process at the interface of stimulated and constitutive exocytosis. The exocytotic mechanisms and sites of regulation in vivo, however, are still poorly understood.




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