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Dysregulation of Intestinal Mucosal Immunity: Implications in Inflammatory Bowel Disease

F. Stephen Laroux¹, Kevin P. Pavlick¹, Robert E. Wolf² and Matthew B. Grisham¹

¹ Departments of Molecular and Cellular Physiology and
² Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932
The mucosal interstitia of the intestine and colon are continuously exposed to large amounts of dietary and microbial antigens. Fortunately, the mucosal immune system has evolved efficient mechanisms to distinguish potentially pathogenic from nonpathological antigens. There are, however, situations in which this immune regulation fails, resulting in chronic gut inflammation.

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