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News Physiol Sci 16: 278-281, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 6, 278-281, December 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Troponin I Isoforms and Chimeras: Tuning the Molecular Switch of Cardiac Contraction

Margaret V. Westfall1,2 and Joseph M. Metzger1

1 Departments of Physiology and
2 Surgery, University of Michigan, Ann Arbor, Michigan 48109-0686
Troponin I, a key myofilament protein, plays a critical role in regulating force generation in striated muscle by acting as a Ca2+-dependent molecular switch. Domains contributing to the functional properties of troponin I have recently been defined in intact myofilaments of adult cardiac myocytes. This has been attained using gene transfer of chimeras derived from two troponin I isoforms expressed during cardiac development.




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