|
|
||||||||
Departments of Physiology and Obstetrics and Gynecology, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505
Placental ischemia during preeclampsia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium. This results in enhanced formation of endothelin and thromboxane and decreased formation of nitric oxide and prostacyclin. These endothelial abnormalities, in turn, cause hypertension by impairing renal pressure natriuresis and increasing total peripheral resistance.
This article has been cited by other articles:
![]() |
C. M. Anderson, F. Lopez, H.-Y. Zhang, Y. Shirasawa, K. Pavlish, and J. N. Benoit Mesenteric Vascular Responsiveness in a Rat Model of Pregnancy-Induced Hypertension Experimental Biology and Medicine, September 1, 2006; 231(8): 1398 - 1402. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. B. D. LaMarca, K. Cockrell, E. Sullivan, W. Bennett, and J. P. Granger Role of Endothelin in Mediating Tumor Necrosis Factor-Induced Hypertension in Pregnant Rats Hypertension, July 1, 2005; 46(1): 82 - 86. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Anderson, F. Lopez, H.-Y. Zhang, K. Pavlish, and J. N. Benoit Reduced Uteroplacental Perfusion Alters Uterine Arcuate Artery Function in the Pregnant Sprague-Dawley Rat Biol Reprod, March 1, 2005; 72(3): 762 - 766. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Maioli, V. Fortino, and A. Pacini Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures Biol Reprod, December 1, 2004; 71(6): 1779 - 1784. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. B.M. Oudejans, J. Mulders, A. M.A. Lachmeijer, M. van Dijk, A. A.M. Konst, B. A. Westerman, I. J. van Wijk, P. A.J. Leegwater, H. D. Kato, T. Matsuda, et al. The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas Mol. Hum. Reprod., August 1, 2004; 10(8): 589 - 598. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |