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News Physiol Sci 16: 282-286, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 6, 282-286, December 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Preeclampsia: Linking Placental Ischemia with Cardiovascular-Renal Dysfunction

Barbara T. Alexander, William A. Bennett, Raouf A. Khalil and Joey P. Granger

Departments of Physiology and Obstetrics and Gynecology, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505
Placental ischemia during preeclampsia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium. This results in enhanced formation of endothelin and thromboxane and decreased formation of nitric oxide and prostacyclin. These endothelial abnormalities, in turn, cause hypertension by impairing renal pressure natriuresis and increasing total peripheral resistance.




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