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pH Homeostasis of Cellular Organelles

Nicolas Demaurex

Department of Physiology, University of Geneva, 1211 Geneva 4, Switzerland
An optimal pH is maintained in each secretory and endocytic organelle by the balance between active H⁺ pumping and passive H⁺ efflux. The progressive acidification of secretory organelles does not reflect an increased proton pumping activity but rather the decreased conduction of a "proton leak" pathway resembling the recently cloned voltage-gated proton channels.

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