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News Physiol Sci 17: 11-16, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 1, 11-16, February 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Of Mice and Worms: Novel Insights Into ClC-2 Anion Channel Physiology

Kevin Strange

Anesthesiology Research Division, Laboratories of Cellular and Molecular Physiology, Departments of Anesthesiology, Molecular Physiology and Biophysics, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232
ClC anion channels are found in all major groups of organisms. Recent studies in nematodes and mice suggest that the function and regulation of ClC-2 have been conserved over vast evolutionary time spans. These studies illustrate the experimental advantages of using genomically defined nonmammalian model organisms for characterizing ClC channel functional genomics.




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