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News Physiol Sci 17: 17-21, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 1, 17-21, February 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?

Håkan Westerblad1, David G. Allen2 and Jan Lännergren1

1 Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; and
2 Department of Physiology and Institute of Biomedical Research, University of Sydney F13, New South Wales 2006, Australia
Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Recent studies on mammalian muscle, however, show little direct effect of acidosis on muscle function at physiological temperatures. Instead, inorganic phosphate, which increases during fatigue due to breakdown of creatine phosphate, appears to be a major cause of muscle fatigue.




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