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Human Myoblast Differentiation: Ca²⁺ Channels are Activated by K⁺ Channels

Laurent Bernheim¹ and Charles R. Bader²

¹ Département de Physiologie, Centre Médical Universitaire, and
² Division de Recherche Clinique Neuro-Musculaire, Département des Neurosciences Cliniques et Dermatologie, Hôpital Cantonal Universitaire, CH-1211 Geneva 4, Switzerland
In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca²⁺ influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K⁺ channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca²⁺ current (mediated by a1H T-type Ca²⁺ channels), which causes intracellular Ca²⁺ to rise.

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