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News Physiol Sci 17: 27-31, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 1, 27-31, February 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Astrocytes Function in Matching Blood Flow to Metabolic Activity

David R. Harder1,2, Chenyang Zhang1 and Debebe Gebremedhin1

1 Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, and
2 Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226
The brain possesses an intrinsic regulatory mechanism to maintain an adequate supply of O2 and nutrition despite local increases in neuronal activity. Brain astrocytes function as an intermediary cell type by responding to glutamate released from activated neurons, and they couple cerebral blood flow by producing cytochrome P-450-derived epoxyeicosatrienoic acids that induce vasodilation and increase capillary density.




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