Physiology Cambridge Electronic Design Limited
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

News Physiol Sci 17: 27-31, 2002;
1548-9213/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harder, D. R.
Right arrow Articles by Gebremedhin, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harder, D. R.
Right arrow Articles by Gebremedhin, D.
News in Physiological Sciences, Vol. 17, No. 1, 27-31, February 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Astrocytes Function in Matching Blood Flow to Metabolic Activity

David R. Harder1,2, Chenyang Zhang1 and Debebe Gebremedhin1

1 Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, and
2 Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226
The brain possesses an intrinsic regulatory mechanism to maintain an adequate supply of O2 and nutrition despite local increases in neuronal activity. Brain astrocytes function as an intermediary cell type by responding to glutamate released from activated neurons, and they couple cerebral blood flow by producing cytochrome P-450-derived epoxyeicosatrienoic acids that induce vasodilation and increase capillary density.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Luria, S. M. Weldon, A. K. Kabcenell, R. H. Ingraham, D. Matera, H. Jiang, R. Gill, C. Morisseau, J. W. Newman, and B. D. Hammock
Compensatory Mechanism for Homeostatic Blood Pressure Regulation in Ephx2 Gene-disrupted Mice
J. Biol. Chem., February 2, 2007; 282(5): 2891 - 2898.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. G. Haydon and G. Carmignoto
Astrocyte control of synaptic transmission and neurovascular coupling.
Physiol Rev, July 1, 2006; 86(3): 1009 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
E. E. Benarroch
Neuron-Astrocyte Interactions: Partnership for Normal Function and Disease in the Central Nervous System
Mayo Clin. Proc., October 1, 2005; 80(10): 1326 - 1338.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. L. Xu, H. M. Koenig, S. Ye, D. L. Feinstein, and D. A. Pelligrino
Influence of the glia limitans on pial arteriolar relaxation in the rat
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H331 - H339.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Simard, G. Arcuino, T. Takano, Q. S. Liu, and M. Nedergaard
Signaling at the Gliovascular Interface
J. Neurosci., October 8, 2003; 23(27): 9254 - 9262.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Gebremedhin, K. Yamaura, C. Zhang, J. Bylund, R. C. Koehler, and D. R. Harder
Metabotropic Glutamate Receptor Activation Enhances the Activities of Two Types of Ca2+-Activated K+ Channels in Rat Hippocampal Astrocytes
J. Neurosci., March 1, 2003; 23(5): 1678 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. Zhang and D. R. Harder
Cerebral Capillary Endothelial Cell Mitogenesis and Morphogenesis Induced by Astrocytic Epoxyeicosatrienoic Acid
Stroke, December 1, 2002; 33(12): 2957 - 2964.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online