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1 Dipartimento di Fisiologia e Biochimica Generali, Laboratorio di Fisiologia Molecolare e Neurobiologia and
2 Istituto Nazionale per la Fisica della Materia, Unità Milano Universita, 20133 Milano, Italy; and
3 School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.
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