Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

News Physiol Sci 17: 32-37, 2002;
1548-9213/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (89)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Accili, E. A.
Right arrow Articles by DiFrancesco, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Accili, E. A.
Right arrow Articles by DiFrancesco, D.
News in Physiological Sciences, Vol. 17, No. 1, 32-37, February 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

From Funny Current to HCN Channels: 20 Years of Excitation

E. A. Accili3, C. Proenza3, M. Baruscotti1 and D. DiFrancesco1,2

1 Dipartimento di Fisiologia e Biochimica Generali, Laboratorio di Fisiologia Molecolare e Neurobiologia and
2 Istituto Nazionale per la Fisica della Materia, Unità Milano Universita, 20133 Milano, Italy; and
3 School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
X. Zhao, A. Bucchi, R. V. Oren, Y. Kryukova, W. Dun, C. E. Clancy, and R. B. Robinson
In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality
J. Physiol., April 1, 2009; 587(7): 1513 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
V. Divakaran and D. L. Mann
The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure
Circ. Res., November 7, 2008; 103(10): 1072 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. E. Mangoni and J. Nargeot
Genesis and Regulation of the Heart Automaticity
Physiol Rev, July 1, 2008; 88(3): 919 - 982.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Akhavan
Contribution of pacemaker channels to autonomous electrical activity of differentiated embryonic stem cells
J. Physiol., May 15, 2008; 586(10): 2425 - 2426.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. J. Bolivar, D. Tapia, G. Arenas, M. Castanon-Arreola, H. Torres, and E. Galarraga
A hyperpolarization-activated, cyclic nucleotide-gated, (Ih-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells
Am J Physiol Cell Physiol, April 1, 2008; 294(4): C893 - C906.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
A. K. Lyashchenko and G. R. Tibbs
Ion binding in the Open HCN Pacemaker Channel Pore: Fast Mechanisms to Shape "Slow" Channels
J. Gen. Physiol., February 25, 2008; 131(3): 227 - 243.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Qu, G. M. Whitaker, L. Hove-Madsen, G. F. Tibbits, and E. A. Accili
Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells
J. Physiol., February 1, 2008; 586(3): 701 - 716.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. A. Rose and W. R. Giles
Natriuretic peptide C receptor signalling in the heart and vasculature
J. Physiol., January 15, 2008; 586(2): 353 - 366.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C.-H. Li, Q. Zhang, B. Teng, S. J. Mustafa, J.-Y. Huang, and H.-G. Yu
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531
Am J Physiol Cell Physiol, January 1, 2008; 294(1): C355 - C362.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. A. Rose, M. G. Kabir, and P. H. Backx
Altered Heart Rate and Sinoatrial Node Function in Mice Lacking the cAMP Regulator Phosphoinositide 3-Kinase-{gamma}
Circ. Res., December 7, 2007; 101(12): 1274 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Baruscotti and R. B. Robinson
Electrophysiology and pacemaker function of the developing sinoatrial node
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2613 - H2623.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. Cheng, K. Kinard, R. Rajamani, and M. C. Sanguinetti
Molecular Mapping of the Binding Site for a Blocker of Hyperpolarization-Activated, Cyclic Nucleotide-Modulated Pacemaker Channels
J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 931 - 939.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. M. Whitaker, D. Angoli, H. Nazzari, R. Shigemoto, and E. A. Accili
HCN2 and HCN4 Isoforms Self-assemble and Co-assemble with Equal Preference to Form Functional Pacemaker Channels
J. Biol. Chem., August 3, 2007; 282(31): 22900 - 22909.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
L. Sartiani, E. Bettiol, F. Stillitano, A. Mugelli, E. Cerbai, and M. E. Jaconi
Developmental Changes in Cardiomyocytes Differentiated from Human Embryonic Stem Cells: A Molecular and Electrophysiological Approach
Stem Cells, May 1, 2007; 25(5): 1136 - 1144.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. Xue, C.-W. Siu, D. K. Lieu, C.-P. Lau, H.-F. Tse, and R. A. Li
Mechanistic Role of If Revealed by Induction of Ventricular Automaticity by Somatic Gene Transfer of Gating-Engineered Pacemaker (HCN) Channels
Circulation, April 10, 2007; 115(14): 1839 - 1850.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. El-Kholy, P. E. MacDonald, J. M. Fox, A. Bhattacharjee, T. Xue, X. Gao, Y. Zhang, J. Stieber, R. A. Li, R. G. Tsushima, et al.
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Pancreatic {beta}-Cells
Mol. Endocrinol., March 1, 2007; 21(3): 753 - 764.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. H. Peck, E. Gaier, E. Stevens, S. Repicky, and R. M. Harris-Warrick
Amine Modulation of Ih in a Small Neural Network
J Neurophysiol, December 1, 2006; 96(6): 2931 - 2940.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. B. Cowan and F. X. McGowan Jr
A Paradigm Shift in Cardiac Pacing Therapy?
Circulation, September 5, 2006; 114(10): 986 - 988.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Bucchi, A. Tognati, R. Milanesi, M. Baruscotti, and D. DiFrancesco
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels
J. Physiol., April 15, 2006; 572(2): 335 - 346.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Wicher, H.-J. Agricola, S. Sohler, M. Gundel, S. H. Heinemann, L. Wollweber, M. Stengl, and C. Derst
Differential Receptor Activation by Cockroach Adipokinetic Hormones Produces Differential Effects on Ion Currents, Neuronal Activity, and Locomotion
J Neurophysiol, April 1, 2006; 95(4): 2314 - 2325.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. Rosenkranz and D. Johnston
Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex.
J. Neurosci., March 22, 2006; 26(12): 3229 - 3244.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. A Simeone, J. M Rho, and T. Z Baram
Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones
J. Physiol., October 15, 2005; 568(2): 371 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Mery, F. Aimond, C. Menard, K. Mikoshiba, M. Michalak, and M. Puceat
Initiation of Embryonic Cardiac Pacemaker Activity by Inositol 1,4,5-Trisphosphate-dependent Calcium Signaling
Mol. Biol. Cell, May 1, 2005; 16(5): 2414 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. P. Johnson Jr. and W. N. Zagotta
The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path
PNAS, February 22, 2005; 102(8): 2742 - 2747.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Catacuzzeno, B. Fioretti, P. Perin, and F. Franciolini
Spontaneous low-frequency voltage oscillations in frog saccular hair cells
J. Physiol., December 15, 2004; 561(3): 685 - 701.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
A. L. Zimmerman
Capturing Ion Channel Gating: A Little Salt on the Tail Does the Trick
J. Gen. Physiol., November 29, 2004; 124(6): 627 - 629.
[Full Text] [PDF]

Home page
 JGPHome page
K. B. Craven and W. N. Zagotta
Salt Bridges and Gating in the COOH-terminal Region of HCN2 and CNGA1 Channels
J. Gen. Physiol., November 29, 2004; 124(6): 663 - 677.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. S. Chan, R. Shigemoto, J. N. Mercer, and D. J. Surmeier
HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons
J. Neurosci., November 3, 2004; 24(44): 9921 - 9932.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Zorn-Pauly, P. Schaffer, B. Pelzmann, P. Lang, H. Machler, B. Rigler, and B. Koidl
If in left human atrium: a potential contributor to atrial ectopy
Cardiovasc Res, November 1, 2004; 64(2): 250 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Barbuti, B. Gravante, M. Riolfo, R. Milanesi, B. Terragni, and D. DiFrancesco
Localization of Pacemaker Channels in Lipid Rafts Regulates Channel Kinetics
Circ. Res., May 28, 2004; 94(10): 1325 - 1331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. A. Rose, A. E. Lomax, C. S. Kondo, M. B. Anand-Srivastava, and W. R. Giles
Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1970 - H1977.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
L. Ferron, V. Capuano, Y. Ruchon, E. Deroubaix, A. Coulombe, and J.-F. Renaud
Angiotensin II Signaling Pathways Mediate Expression of Cardiac T-Type Calcium Channels
Circ. Res., December 12, 2003; 93(12): 1241 - 1248.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Fernandez-Velasco, N. Goren, G. Benito, J. Blanco-Rivero, L. Bosca, and C. Delgado
Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts
J. Physiol., December 1, 2003; 553(2): 395 - 405.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. A. Swanson, B. Gloss, D. D. Belke, M. Kaneshige, S.-Y. Cheng, and W. H. Dillmann
Cardiac Expression and Function of Thyroid Hormone Receptor {beta} and Its PV Mutant
Endocrinology, November 1, 2003; 144(11): 4820 - 4825.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Stieber, A. Thomer, B. Much, A. Schneider, M. Biel, and F. Hofmann
Molecular Basis for the Different Activation Kinetics of the Pacemaker Channels HCN2 and HCN4
J. Biol. Chem., September 5, 2003; 278(36): 33672 - 33680.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
D. DiFrancesco
If inhibition: a novel mechanism of action
Eur. Heart J. Suppl., September 1, 2003; 5(suppl_G): G19 - G25.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
C. Altomare, B. Terragni, C. Brioschi, R. Milanesi, C. Pagliuca, C. Viscomi, A. Moroni, M. Baruscotti, and D. DiFrancesco
Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node
J. Physiol., June 1, 2003; 549(2): 347 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Hiraoka
A Novel Action of Insulin on Cardiac Membrane
Circ. Res., April 18, 2003; 92(7): 707 - 709.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
Y. H. Zhang and J. C. Hancox
A Novel, Voltage-Dependent Nonselective Cation Current Activated by Insulin in Guinea Pig Isolated Ventricular Myocytes
Circ. Res., April 18, 2003; 92(7): 765 - 768.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Sartiani, P. Bochet, E. Cerbai, A. Mugelli, and R. Fischmeister
Functional expression of the hyperpolarization-activated, non-selective cation current If in immortalized HL-1 cardiomyocytes
J. Physiol., November 15, 2002; 545(1): 81 - 92.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Tran, C. Proenza, V. Macri, F. Petigara, E. Sloan, S. Samler, and E. A. Accili
A Conserved Domain in the NH2 Terminus Important for Assembly and Functional Expression of Pacemaker Channels
J. Biol. Chem., November 8, 2002; 277(46): 43588 - 43592.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online