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News Physiol Sci 17: 6-10, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 1, 6-10, February 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Thrombopoietin: The Novel Hepatic Hormone

Eva-Maria Wolber and Wolfgang Jelkmann

Institute of Physiology, Medical University of Luebeck, D-23538 Luebeck, Germany
The glycoprotein thrombopoietin (TPO) is the major stimulator of megakaryopoiesis and platelet production. Hepatocytes express TPO mRNA at a constant rate. The plasma TPO level is inversely correlated to the mass of megakaryocytes and platelets, which degrade the hormone following its binding to specific membrane receptors.




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