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News Physiol Sci 17: 56-61, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 2, 56-61, April 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Plasminogen Activator Inhibitor 1: Physiological and Pathophysiological Roles

Bernd R. Binder, Günter Christ, Florian Gruber, Nelly Grubic, Peter Hufnagl, Michael Krebs, Judit Mihaly and Gerald W. Prager

Department of Vascular Biology and Thrombosis Research, University of Vienna, A-1090 Vienna, Austria
Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.




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