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1 Department of Physiology, Department of Pharmacology, University of Arizona College of Medicine, Tucson Arizona 85724-5051;
2 Department of Physiology, Weill Medical College of Cornell University, New York, New York 10021-4896
Mammalian aquaporins are part of the diverse major intrinsic protein family of water and solute channels. Intriguing links exist in structural and functional properties between aquaporins and ion channels. A novel role for aquaporin-1 as a gated ion channel reshapes our current views of this ancient family of transmembrane channel proteins.
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