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New Roles for Old Holes: Ion Channel Function in Aquaporin-1

Andrea J. Yool¹ and Alan M. Weinstein²

¹ Department of Physiology, Department of Pharmacology, University of Arizona College of Medicine, Tucson Arizona 85724-5051;
² Department of Physiology, Weill Medical College of Cornell University, New York, New York 10021-4896
Mammalian aquaporins are part of the diverse major intrinsic protein family of water and solute channels. Intriguing links exist in structural and functional properties between aquaporins and ion channels. A novel role for aquaporin-1 as a gated ion channel reshapes our current views of this ancient family of transmembrane channel proteins.

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