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News Physiol Sci 17: 73-76, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 2, 73-76, April 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

ADAM-Mediated Shedding and Adhesion: a Vascular Perspective

Barbara Herren

Cardiovascular Research Division, Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland
Proteolytic conversion (shedding) of membrane-bound proteins to soluble forms is a novel regulatory mechanism mediated by enzymes called a disintegrin and metalloproteases (ADAMs). In this review, the potential importance of ADAMs in vascular physiology and disease, especially in relation to atherosclerosis, will be highlighted.




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