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Cardiovascular Research Division, Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland
Proteolytic conversion (shedding) of membrane-bound proteins to soluble forms is a novel regulatory mechanism mediated by enzymes called a disintegrin and metalloproteases (ADAMs). In this review, the potential importance of ADAMs in vascular physiology and disease, especially in relation to atherosclerosis, will be highlighted.
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