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News Physiol Sci 17: 82-85, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 2, 82-85, April 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Insulin-Like Growth Factor-I: Compartmentalization Within the Somatotropic Axis?

Andrew A. Butler1, Shoshana Yakar2 and Derek LeRoith2

1 The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201; and
1 Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1758
Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.




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