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Metabolic Diseases: the Environment Determines the Odds, Even for Genes

Ingrid Schmidt

Max-Planck-Institut für physiologische und klinische Forschung, W. G. Kerckhoff-Institut, D-61231 Bad Nauheim, Germany
The odds for well-being or illness are determined by the interplay of genetic and environmental impacts. In this review, normal and disturbed body weight regulation are used to demonstrate the role of integrative bioresearch in bridging the gap between identified genotypes and an understanding of the functions of redundant and plastic control systems underlying phenotypes.

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				K. Weide, N. Christ, K. M. Moar, J. Arens, A. Hinney, J. G. Mercer, S. Eiden, and I. Schmidt Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice Physiol Genomics, March 18, 2003; 13(1): 47 - 56. [Abstract] [Full Text] [PDF]

				C. Kellendonk*, S. Eiden*, O. Kretz, G. Schutz, I. Schmidt, F. Tronche, and E. Simon Inactivation of the GR in the Nervous System Affects Energy Accumulation Endocrinology, June 1, 2002; 143(6): 2333 - 2340. [Abstract] [Full Text] [PDF]