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The Lactate Paradox in Human High-Altitude Physiological Performance

P. W. Hochachka^1,2,3, C. L. Beatty¹, Y. Burelle¹, M. E. Trump¹, D. C. McKenzie³ and G. O. Matheson⁴

¹ Department of Zoology,
² Department of Radiology, and
³ Sports Medicine Division, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada; and
⁴ Department of Functional Restoration, Sports Medicine Division, Stanford University, Stanford, California 94305-6175
For many years, physiologists have puzzled over the observation that, during maximum aerobic exercise, high-altitude natives generate lower-than-expected amounts of lactate; the higher the altitude, the lower the postexercise blood lactate peak. This paradoxical situation may be caused mainly by upregulated metabolic control contributions from cell ATP demand and ATP supply pathways.

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