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1 Department of Physiology, Akita University School of Medicine, and
2 Core Research for Evolutional Science and Technology, Japan Science and Technology Cooperation, 1-1-1 Hondo, Akita 010-8543, Japan
Rapid minimization of energy consumption in excitable tissues is effective protection from lethal effects of extreme metabolic stress. The ATP-sensitive K+ channels in the brain respond in ATP-depleted metabolic states such as hypoxia and may be involved in the protection mechanism against energy-consuming generalized seizure.
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