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News Physiol Sci 17: 127-130, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 3, 127-130, June 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

ATP-Sensitive K+ Channels in the Brain: Sensors of Hypoxic Conditions

Katsuya Yamada1 and Nobuya Inagaki1,2

1 Department of Physiology, Akita University School of Medicine, and
2 Core Research for Evolutional Science and Technology, Japan Science and Technology Cooperation, 1-1-1 Hondo, Akita 010-8543, Japan

Rapid minimization of energy consumption in excitable tissues is effective protection from lethal effects of extreme metabolic stress. The ATP-sensitive K+ channels in the brain respond in ATP-depleted metabolic states such as hypoxia and may be involved in the protection mechanism against energy-consuming generalized seizure.




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