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News Physiol Sci 17: 87-92, 2002;
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 3, 87-92, June 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Gene Therapy of Hematopoietic Stem Cells: Strategies for Improvement

Johann P. Hossle, Reinhard A. Seger and Dirk Steinhoff

Division of Immunology/Hematology/Oncology, University-Children's Hospital Zurich, CH-8032 Zurich, Switzerland
Gene therapy of hematopoietic stem cells (HSC) is limited by low frequency of the target cells, their quiescent nature, poor engraftment of treated HSC, and lack of a selective growth advantage of genetically modified cells. Lentiviral vectors combined with positive selection strategies using conditional cell-growth switches should allow for improvement.






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