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News Physiol Sci 17: 131-137, 2002; doi:10.1152/nips.01388.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 4, 131-137, August 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Mechanism(s) of Hypoxic Pulmonary Vasoconstriction: Potassium Channels, Redox O2 Sensors, and Controversies

Stephen Archer and Evangelos Michelakis

Department of Medicine (Cardiology) and the Vascular Biology Group, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in PO2 are sensed by a vascular redox O2 sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K+ channels, thereby controlling membrane potential, Ca2+ entry, and tone.




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