Physiology AJP: Heart and Circulatory Physiology
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News Physiol Sci 17: 138-143, 2002; doi:10.1152/nips.01379.2001
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 4, 138-143, August 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Central Synaptic Integration: Linear After All?

C. Stricker

Institute of Neuroinformatics, University and Federal Institute of Technology Zürich, CH-8057 Zürich, Switzerland
Unitary synaptic currents in hippocampus show small variability. Experimental evidence suggests that the neuron is endowed with mechanisms to reduce location-dependent differences in amplitude and time course of synaptic events, contributing to small variability. These mechanisms may allow the neuron to count individual quanta and thereby linearize integration of unitary events.






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