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News Physiol Sci 17: 144-149, 2002; doi:10.1152/nips.01385.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 4, 144-149, August 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Rapidly Exchanging Ca2+ Stores: Ubiquitous Partners of Surface Channels in Neurons

Jacopo Meldolesi

Department of Neuroscience and Excellence Centre in Cell Differentiation, Vita-Salute San Raffaele University, and DIBIT, San Raffaele Institute, 20132 Milan, Italy
Neuronal rapidly exchanging Ca2+ stores coincide with the endoplasmic reticulum and possess ample, nonrandom distribution, dual receptor channels, IP3 and ryanodine receptors, and heterogeneous membranes. Because of these properties, the stores are able to reinforce and expand the Ca2+ signals generated at the surface, working as partners of voltage- and receptor-gated channels.




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