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1 Centro de Estudios Científicos (CECS), Valdivia;
2 Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile;
3 Department of Physiology and Anesthesiology, UCLA School of Medicine, Los Angeles, California 90095; and
4 Departamento de Biofísica, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
Ca2+-activated K+ channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory b-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.
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