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Laminin Binding Conveys Mechanosensing in Endothelial Cells

Torsten Gloe and Ulrich Pohl

Institute of Physiology, Ludwig Maximilians University, 80336 Munich, Germany
In endothelial cells, forces like shear stress are transferred to focal adhesion sites and activate in concert with matrix receptor kinases, leading to an initiation of signaling cascades. The laminin binding protein is one of these matrix receptors and is critically involved in sensing and quantification of shear stress.

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