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News Physiol Sci 17: 181-184, 2002; doi:10.1152/nips.01383.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 5, 181-184, October 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Who Discovered the Frank-Starling Mechanism?

Heinz-Gerd Zimmer

Carl-Ludwig-Institute of Physiology, University of Leipzig, D-04103 Leipzig, Germany
In 1866 at Carl Ludwig’s Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.






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